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Regenerative Injections

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Prolotherapy

Non-surgical method of tightening connective tissue

Prolotherapy is an injection therapy designed to trigger strengthening and remodeling of connective tissue. Human bodies often do not completely heal from traumatic strain and wear and tear injuries. Rather some degree of ligament laxity and scar tissue remain.  Brilliant built-in mechanisms of adaptation compensate for these effects, but at some point the tissues begin to complain, contributing to chronic patterns of pain or decreased function.  Prolotherapy has the unique ability to address these injuries in a way that wakes up the body's healing potential, sometimes reversing patterns of dysfunction that have been present for decades. It utilizes a simple solution made from dextrose, procaine and saline.

Prolotherapy + PRP ​
Pre-appointment

Wear comfortable clothing. Make sure to eat a light healthy meal and be well hydrated for your visit.

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NO NSAIDS in your system for preferably two weeks prior to treatment. (Ibuprofen or Naprosyn or other anti-inflammatory meds.)

​Post-appointment

Care + Timeline

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Specifics depend on area being treated, but generally speaking:

 

​2-3 days Rest the affected area. Though it varies, there is usually some discomfort + swelling

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Do  elevate the area, use heat​​

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Do not  take Ibuprofen or Naprosyn or other anti-inflammatory meds as they block the healing response we are inducing

 

​1 week  Continue to take it easy, with gradual use as pain allows​

 

1 month  For the most part, full activity can be resumed, but listen to your body and push only as far as it allows​

 

2 months+  Strengthening from Prolotherapy with occur over a period of up to 2 months, whilst PRP has a slower, stronger response, rarely noticeable before 3 weeks and continuing even beyond 6 months 

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*While some experience near-immediate relief, it may take multiple rounds to repair more significant tissue damage

PRP
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PRP - Platelet Rich Plasma

PRP is fast becoming a mainstay of orthopedic medicine, being used in surgery and many university orthopedic centers. It has wide-ranging potential in supporting health through the use of the concentrated growth factors found in your very own platelets. These are the very same chemical signals that instigate and organize healing from injuries in life in general. In this technique, blood is drawn and processed to remove the red blood cells and concentrate the platelets. This solution is then re-injected into injured tissue or joints stimulating healing and repair.​

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Urinary Incontinence and Pelvic Floor Dysfunction

PRP has proven to be an immensely successful approach to rejuvenation of injured, arthritic, or overstretched tissue.  It is no surprise that clinics around the world have begun reporting on success in treating common pelvic floor disease common after childbirth, such as urinary incontinence and prolapse.  Pregnancy and childbirth exert high forces on the structure of the pelvic floor.  One third of new mothers experience incontinence during pregnancy and after childbirth and in many cases this does not correct over time.  In contrast, among women who have had five or more children, OVER 90% have significant urinary incontinence.  This is the result of stretched and damaged connective tissue (ligaments) that are responsible for holding the pelvic organs in place.  Marked pelvic organ prolapse can be the end result of these injuries, however even without severe prolapse, significant practical dysfunction does occur.

 

We have developed a treatment using PRP, to address the complex and somewhat difficult to reach ligament structures involved in these pelvic floor injuries, and have already had significant clinical success with patients. 

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The Nerve Connection

Our use of PRP has evolved over time and in collaboration with practitioners of regenerative medicine around the country. In addition to the treatment of the usual joint degeneration, meniscus and labral tears, and ligament and tendon injuries, we now—as a matter of course—include a consideration of the nerves that feed the area in question. Hydrodissection and Neural Therapies (discussed below) are essential to guarantee the best results in treating chronic injuries. 

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Nerves are involved in all chronic pain patterns

 

Not only can nerves be injured through traction or compression in the traumatic process, and not only can they be compromised from poor blood flow caused by tension or scarring along their path,  but in fact just the constant repetitive processing of pain signal over time creates dysfunction in the nerve beds, reflected in patterns ascending all the way to the brain. Without addressing these issues, reaching the full potential of healing is not possible. Therefore at our clinic we now fully integrate PRP ultrasound injections with regional nerve therapies.

Repair torn or frayed ligaments without surgery

Pelvic floor

1

The Cause

Chronic Injury, either from an accident or simply prolonged wear-and-tear, causes connective tissue to stretch and fray

   

torn connective tissue ligamnet tear knee pain
Neural Therapy
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Neural Therapy

Neural Therapy is a well established technique, utilizing dextrose, anesthetic and/or ozone injections into foci of neural irritation. This is often done just under the skin over key nerves, in so-called trigger points in muscle, or deeper yet into key sympathetic centers, ganglia, or nerve roots. Chronic pain is very often maintained in part through irritated local, segmental or regional neural feedback loops.  In many cases this explains why traditional pain management fails to help, as typical medicines and therapy do not directly address this pattern held in the nerves, sometimes almost by habit. The chronic irritation and shock in the nervous system becomes a form of "injury" in its own right.  Neural therapy allows this aspect of the chronic pattern to be treated and released. In cases of chronic pain, it is sometimes the ONLY intervention that can help actually change the pattern.

Treated Conditions 

These therapies can address Chronic Pain across the entire neuromusculoskeletal system

Specific conditions

Rotator cuff 

Tennis elbow

Tendinitis

Sports Injuries

Meniscus tear

Degenerative disc disease

Arthritis 

Whiplash

Trauma

Ligament injury

Frayed tendons / 

connective tissue

And more

Hydrodissection
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Hydrodissection

Hydrodissection is an ultrasound guided injection technique which uses relaxing and anti-inflammatory solutions to open spaces around inflamed or irritated nerves. This can be helpful for example in carpal tunnel, any form of nerve entrapment, or to help relax chronic nerve inflammation from any cause. This is technically similar to the nerve blocks done in anesthesia for surgery, except that what is injected is not designed to completely block the nerve, rather to free the nerve in its path and reduce inflammation and irritation of the nerve or nerve fiber grouping.

Interosseus Thrpy
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Interosseus Therapies

MRI has shown us that trauma to the body also affects the interosseous spaces—the areas between bones. Modic changes in the spine and edema in the bone marrow are often seen in the vicinity of joint injuries. The interosseous space is also home to pluripotent cells, which have been used very effectively in treatment of severe arthritis. IV's and forms of PRP given in the interosseous space can have a profound impact on nearby joints and possibly the entire body.

Bocellular
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Biocellular Therapy

In our culture, fat sure gets a bad rap, BUT fat tissue (aka adipose) turns out to be incredibly important for health.  It does not just store clean energy, but regulates whole body metabolism.  It does not just insulate the body, but regulates whole body temperature.  It mechanically cushions organs and important tendons and ligaments, but also maintains and heals them. This healing function of adipose was recognized and harnessed first in the field of plastic surgery, and has now found a home in regenerative orthopedic medicine.  This is because adipose tissue contains high numbers of pluripotent cells. These are cells that build new blood vessels, reduce tissue inflammation, and that can literally (and amazingly) differentiate into any type of connective tissue. This means they can actually become tendon, ligament, cartilage, bone, muscle etc.

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These cells are present in adipose in high numbers, even into old age, sometimes exceeding one million cells per tablespoon. In fact, adipose (fat) tissue is one of the richest sources of mesenchymal cells in the body, providing up to 500 times more cells per gram than bone marrow.

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To put it briefly, adipose tissue is a regenerative powerhouse.  Your fat tissue is liquid gold.  

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We began offering this therapy in 2025, in a form known as "Biocellular Matrix" where carefully prepared adipose tissue is mixed with PRP (made from the patient's blood).  This combination has profound synergies and results in even greater healing. This mixture is then injected in a way similar to prolotherapy or PRP, under ultrasound guidance, into damaged, arthritic or painful body areas to stimulate healing.  So far we are very excited with our results and will be tracking all patients over time going forward.

 

The healing arc after Biocellular treatment goes on for a solid 9 months, during which time continued healing and improvements can occur.  I think of it as a kind "gestation" during which time the powerful processes triggered by the growth factors in the PRP and the pluripotent cells in the adipose play out.

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The procedure itself involves first a blood draw to isolate PRP and something called platelet poor plasma (PPP) which we also use to advantage.  Then we do a low volume liposuction procedure, and the resulting adipose is prepared according to a specific protocol to concentrate the cells and produce an injectable matrix. In our view this is currently the pinnacle treatment in regenerative medicine, and the most likely treatment in our offerings to produce one-off, and long lasting tissue repair.

For these therapies, please contact us to book a general consult

Office of Dr Chris Montanaro

411 Coyote Street

Nevada City, CA 95959

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Hours:

Our hours vary, but we are generally here:

Mon/Tue/Thurs: 10am - 5pm

Fridays: 1p - 5pm

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Please note that we are closed on Wednesdays.

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530.505.3375  (phone)

530.730.9793  (fax)

© 2025 by Dr. Chris Montanaro

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